About Our Headquarters  

As of June 2025, the South Carolina Department of Public Health’s (DPH) headquarters are co-located at the State of South Carolina Health Campus with the South Carolina Department of Behavioral Health and Developmental Disabilities, allowing for increased collaboration, coordination and communication between the two cabinet agencies. The state’s health campus is located at 400 Otarre Parkway in Cayce.

Services Not Affected by Headquarters Relocation

While the location of DPH’s headquarters has changed, some of the agency’s Columbia-based services will remain in place for now.

Vital Records

Birth and death certificates, marriage records or divorce reports will continue to be issued at DPH’s state Vital Records office, located at 2600 Bull St., Columbia, and at Vital Records offices across the state. These records are not available at the state’s health campus.

Richland County Health Department Services

Family planning, immunizations, STD/HIV/Hep C, Tuberculosis testing, Opioid OD Kits, and WIC services will continue to be provided at the Richland County Health Department, located at 2000 Hampton St., Columbia, and at public health clinics statewide.
 


Once Richland County completes its Family Services Center, the state’s Vital Records office and the Richland County Health Department will move to this new location at the former Columbia Place Mall. DPH will provide notice of these moves in advance.


Contact Information

Phone Numbers

All DPH-affiliated phone numbers remain the same. To reach DPH’s main line, please call (803) 898-3300. To reach the Care Line for health referrals or to make an appointment at a local health department, please call 1-855-472-3432.

Mailing Addresses

The mailing addresses for DPH headquarters have been updated and are provided below:

Payments

Accounts Receivable
S.C. Department of Public Health
PO Box 2629
West Columbia, SC 29171

Other USPS Mail

Include Specific Area/Office
S.C. Department of Public Health
P.O. Box 2046
West Columbia, SC 29171

Packages

Include Specific Area/Office
S.C. Department of Public Health
Building E Loading Dock
400 Otarre Parkway
Cayce, SC 29033

Contact Us

If you have any questions about DPH headquarters or services, please contact us.