Updated: Feb. 12, 2026

About Our Headquarters  

As of June 2025, the South Carolina Department of Public Health’s (DPH) headquarters are co-located at the State of South Carolina Health Campus with the South Carolina Department of Behavioral Health and Developmental Disabilities, allowing for increased collaboration, coordination and communication between the two cabinet agencies. The state’s health campus is located at 400 Otarre Parkway in Cayce.

Services Not Affected by Headquarters Relocation

While the location of DPH’s headquarters has changed, some of the agency’s Columbia-based services will remain in place for now.

Vital Records

Birth and death certificates, marriage records or divorce reports will continue to be issued at DPH’s state Vital Records office, located at 2600 Bull St., Columbia, and at Vital Records offices across the state. These records are not available at the state’s health campus.

Richland County Health Department Services

Family planning, immunizations, STD/HIV/Hep C, Tuberculosis testing, Opioid OD Kits, and WIC services will continue to be provided at the Richland County Health Department, located at 2000 Hampton St., Columbia, and at public health clinics statewide.
 

Contact Information

Phone Numbers

All DPH-affiliated phone numbers remain the same. To reach DPH’s main line, please call (803) 898-3300. To reach the Care Line to get help finding services, or to make an appointment at a health department, please call 1-855-472-3432.

Mailing Addresses

The mailing addresses for DPH headquarters have been updated and are provided below:

Payments

Accounts Receivable
S.C. Department of Public Health
PO Box 2629
West Columbia, SC 29171

Other USPS Mail

Include Specific Area/Office
S.C. Department of Public Health
P.O. Box 2046
West Columbia, SC 29171

Packages

Include Specific Area/Office
S.C. Department of Public Health
Building E Loading Dock
400 Otarre Parkway
Cayce, SC 29033

Physical Address

S.C. Department of Public Health 
400 Otarre Parkway 
Cayce, SC 29033 

What Visitors Need to Know

Tobacco-Free Campus

DPH has a Smoke and Tobacco-Free policy in place at South Carolina Health Campus and all other locations. The use of tobacco and smoking products — including dip/chew/oral nicotine pouches, e-cigarettes/vapes, and other tobacco products — is prohibited on DPH property. The policy applies 24 hours a day, seven days a week to all DPH employees, clients, contractors, vendors, and visitors (“covered individuals”) while on DPH property. In accordance with our commitment to promoting and protecting public health, all DPH offices and grounds are 100% smoke and tobacco-free campuses.

Campus Access

All visitors should enter the campus at the 12th Street Extension entrance. Visitors should enter through the far-left lane nearest the guard station and check in at the gate. The guard asks visitors for their identification, the purpose of the visit, the visiting agency and employee, and logs license plates. 

Parking

Visitors may park almost anywhere on campus, however a spot close to the Building D entrance is recommended, if available. The parking garages have two levels with stair access; they do not have elevators. All handicap parking spaces are located on the top levels of the parking garages and in the surface parking lots. Visitors should not park on the loading dock or ramp at Building E, as this space is for delivery vehicles only. 

Building Access

Visitors must use the entrance at Building D and check in with the main lobby guard, who will provide them with a visitor badge. The guard will contact the agency point of contact. The person the visitor is meeting with, or their designee, must meet them in the lobby and escort them to the meeting place. After the meeting, a DPH employee must escort the visitor back to Building D to return the visitor's badge and sign out.

Unexpected/unannounced visitors are expected to follow the same process and provide the same information.

Contact Us

If you have any questions about DPH headquarters or services, please contact us.