About Our Headquarters
As of June 2025, the South Carolina Department of Public Health’s (DPH) headquarters are co-located at the State of South Carolina Health Campus with the South Carolina Department of Behavioral Health and Developmental Disabilities, allowing for increased collaboration, coordination and communication between the two cabinet agencies. The state’s health campus is located at 400 Otarre Parkway in Cayce.
Services Not Affected by Headquarters Relocation
While the location of DPH’s headquarters has changed, some of the agency’s Columbia-based services will remain in place for now.
Vital Records
Birth and death certificates, marriage records or divorce reports will continue to be issued at DPH’s state Vital Records office, located at 2600 Bull St., Columbia, and at Vital Records offices across the state. These records are not available at the state’s health campus.
Richland County Health Department Services
Family planning, immunizations, STD/HIV/Hep C, Tuberculosis testing, Opioid OD Kits, and WIC services will continue to be provided at the Richland County Health Department, located at 2000 Hampton St., Columbia, and at public health clinics statewide.
Once Richland County completes its Family Services Center, the state’s Vital Records office and the Richland County Health Department will move to this new location at the former Columbia Place Mall. DPH will provide notice of these moves in advance.
Contact Information
Phone Numbers
All DPH-affiliated phone numbers remain the same. To reach DPH’s main line, please call (803) 898-3300. To reach the Care Line for health referrals or to make an appointment at a local health department, please call 1-855-472-3432.
Mailing Addresses
The mailing addresses for DPH headquarters have been updated and are provided below:
Payments
Accounts Receivable
S.C. Department of Public Health
PO Box 2629
West Columbia, SC 29171
Other USPS Mail
Include Specific Area/Office
S.C. Department of Public Health
P.O. Box 2046
West Columbia, SC 29171
Packages
Include Specific Area/Office
S.C. Department of Public Health
Building E Loading Dock
400 Otarre Parkway
Cayce, SC 29033
Physical Address
Campus Access for Visitors
All visitors should enter the campus at the 12th Street Extension entrance. Visitors should enter through the far-left lane nearest the guard station, where they will check in at the gate. The guard will ask them to provide their identification, license plate number, purpose for their visit, and agency they are visiting.
Building Access for Visitors
Visitors must use the main entrance at Building D and check in with the main lobby guard, who will provide them with a visitor badge (if required). The guard will contact the agency point of contact. The person the visitor is meeting with, or their designee, must meet them in the lobby and escort them to the meeting place (if required).
After the meeting, a DPH employee must escort the visitor back to Building D so they can return the visitor badge and sign out.
Unexpected/unannounced visitors are expected to follow the same process and provide the same information.
Parking
Visitors may park almost anywhere on campus, however a spot close to the Building D entrance is recommended, if available. The two parking garages have two levels with stair access; they do not have elevators. All handicap parking spaces will be located on the top levels of the parking garages and in the surface parking lots. Visitors should not park on the loading dock or ramp at Building E, as this space is for delivery vehicles only.
Contact Us
If you have any questions about DPH headquarters or services, please contact us.